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目的观察阿米替林治疗功能性消化不良的疗效。方法将84例功能性消化不良患者随机分为治疗组和对照组各42例。对照组予奥美拉唑联合多潘立酮治疗,治疗组在对照组基础上加用阿米替林治疗。观察比较2组临床疗效及症状改善情况。结果治疗组总有效率为85.7%高于对照组的78.6%,差异有统计学意义(P<0.05)。治疗前2组主要症状差异无统计学意义(P>0.05)。治疗后2组主要症状发生率均低于治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05)。结论阿米替林联合奥美拉唑、多潘立酮片治疗功能性消化不良可以更好改善临床症状,提高疗效。
Objective To observe the efficacy of amitriptyline in treating functional dyspepsia. Methods Eighty-four patients with functional dyspepsia were randomly divided into treatment group (n = 42) and control group (n = 42). The control group was treated with omeprazole and domperidone, and the treatment group was treated with amitriptyline on the basis of the control group. The clinical efficacy and symptom improvement in two groups were observed and compared. Results The total effective rate was 85.7% in the treatment group and 78.6% in the control group, with significant difference (P <0.05). There was no significant difference in the main symptoms between the two groups before treatment (P> 0.05). After treatment, the incidence of the two main symptoms were lower than before treatment, and the treatment group was lower than the control group, the difference was statistically significant (P <0.05). Conclusion Amitriptyline combined with omeprazole and domperidone tablets in treating functional dyspepsia can improve the clinical symptoms and improve the curative effect.