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Background Although acute rheumatic fever and rheumatic heart disease are now rare in affluent popula-tions,they remain major health issues in developing countries such as China. Rheumatic mitral stenosis is the most common valvular disease during pregnancy. Some patients can receive percutaneous balloon mitral valvulo-plastyduring pregnancy and obtain good outcomes. Methods A retrospective study of 14 women undergoing percutaneous balloon mitral valvuloplasty with rheumatic mitral valve stenosis during pregnancy in our hospital from Jan 2014 to Oct 2019 was conducted. The mateal and fetal outcomes were analyzed. Results Percutane-ous balloon mitral valvuloplasty was successful in all patients with significant improvement in their mitral valve area(pre-operation:0.83 ± 0.21 cm2 and post-operation:1.64 ± 0.27 cm2 ,P<0.05). Pulmonary artery systolic pressure(pre-operation:69.62±28.27 mmHg and post-operation:37.23±12.65 mmHg,P<0.05)was significantly decreased. All 14 patients had an uneventful course afterthe operation. The total number of newbos was 14, none of whom required intensive care monitoring,and no malformations were found. Conclusions Percutane-ous balloon mitral valvuloplasty performed during pregnancy with necessary precautions is feasible and effective-for the mother and mightbe safe forthe fetus. There is marked symptomatic relief,along with good mateal and fetal outcomes.