联苯苄唑(白霉唑,bifonazole,1),是西德 Bayer 研究中心合成的一种不含卤素的咪唑类抗真菌药,化学名为1-(ρ,α-二苯基苄基)咪唑,其抗菌谱与克霉唑和益康唑类似,但有很强的皮肤渗透性,在表皮深层药物浓度可达其对皮肤真菌体外最低抑菌浓度的几倍。一次涂布后,皮肤中有效浓度能 Bifonazole (bifonazole, 1) is a non-halogenated imidazole antifungal drug synthesized by Bayer Research Center in West Germany. Its chemical name is 1- (ρ, α-diphenylbenzyl) Imidazole, its antibacterial spectrum and clotrimazole and econazole similar, but has a strong skin permeability in the epidermis deep drug concentration up to its skin fungus in vitro minimum inhibitory concentrations several times. Once coated, the effective concentration of the skin can