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目的:探讨癌基因 MDM2和抑癌基因 GADD、p5 3与子宫内膜增生过长、子宫内膜癌的关系。方法:应用 MDM2、GADD、p5 3单克隆抗体对 10 0例子宫内膜增生过长、宫内膜癌进行免疫组织化学染色。结果 :MDM2、p5 3在良恶性组间差异有统计学意义 (P <0 .0 5 ) ,而 GADD各组间无差异。 3种基因表达存在相关性 ,MDM2与p5 3呈正相关 ,GADD与 p5 3呈负相关。MDM2与 GADD表达与宫内膜癌的组织分型、分级无关。 结论:MDM2、p5 3参与了子宫内膜癌的发生、发展 ,GADD则间接通过 p5 3而发挥其抑癌功能。
Objective: To investigate the relationship between oncogene MDM2 and tumor suppressor genes GADD, p5 3 and endometrial hyperplasia and endometrial carcinoma. Methods: The MDM2, GADD and p5 3 monoclonal antibodies were used to detect the endometrial hyperplasia in 10 cases. Endometrial carcinoma was immunohistochemically stained. Results: There was a significant difference between MDM2 and p5 3 in benign and malignant groups (P <0.05), but there was no difference between GADD groups. There was a positive correlation between the three gene expressions, MDM2 and p5 3, and negative correlation between GADD and p5 3. MDM2 and GADD expression and endometrial cancer tissue type, grade has nothing to do. Conclusion: MDM2 and p5 3 are involved in the development and progression of endometrial carcinoma. GADD exerts its anti-cancer function indirectly through p5 3.