以兔高脂血清培养内皮细胞 (EC)造成离体动脉粥样硬化 (AS)模型 ,应用相差显微镜、电镜、脂蛋白 (a) [Lp(a) ]、组织型纤溶酶原激活物 (t PA)及其抑制物 (PAI)的测定 ,观察软脉宁对脂质过氧化损伤的EC形态、结构和纤溶功能的保护作用。结果表明 :软脉宁可使由脂质过氧化作用造成的EC细胞收缩及生物膜系统损伤的程度减轻 ,并使LP(a)浓度显著降低、t PA活性显著增高、PAI活性显著降低 ,且LP(a)与PAI呈正相关。提示 :软脉宁通过减轻EC脂质过氧化损伤程度 ,降低LP(a)浓度 ,维护了纤溶功能的平衡 ,抑制血栓的生成 ,从而阻止了AS的形成和发展 Culture of endothelial cells (EC) with rabbit high-fat serum results in an isolated atherosclerosis (AS) model. Phase contrast microscope, electron microscopy, lipoprotein (a) [Lp(a)], tissue-type plasminogen activator ( The determination of tPA and its inhibitors (PAI) was used to observe the protective effect of Huaxining on the morphology, structure and fibrinolytic function of EC induced by lipid peroxidation. The results showed that the degree of contraction of the EC cells and the damage of the biofilm system caused by lipid peroxidation could be reduced, and the concentration of LP(a) was significantly decreased, the activity of t PA was significantly increased, and the activity of PAI was significantly decreased. (a) Positive correlation with PAI. It is suggested that: jinganing can reduce the level of LP(a) by reducing the lipid peroxidation damage of EC, maintain the balance of fibrinolytic function, inhibit the formation of thrombus, and prevent the formation and development of AS.