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目的观察睡前应用中效胰岛素联合口服磺脲类降糖药治疗2型糖尿病的临床效果。方法选择45例单用口服降糖药治疗失效的2型糖尿病患者,给予格列吡嗪及睡前加用中效胰岛素治疗,观察空腹血糖、餐后2 h血糖、糖化血红蛋白的变化及不良反应。结果睡前加用中效胰岛素治疗3个月后,FBG(空腹血糖)和2 h BG(餐后二小时血糖),HbAlc(糖化血红蛋白)水平均较治疗前显著降低(P均<0.01)。结论对单用口服降糖药效果欠佳的2型糖尿病,睡前加用中效胰岛素治疗效果显著。
Objective To observe the clinical effect of moderate-effect insulin plus oral sulfonylurea hypoglycemic agents on type 2 diabetes patients before bedtime. Methods 45 patients with type 2 diabetes treated with oral hypoglycemic agents alone were treated with glipizide and before treatment with moderate-acting insulin. Changes in fasting blood glucose, postprandial blood glucose 2 h, HbA1c and adverse reactions . Results After 3 months of treatment with fasting insulin, the levels of FBG (fasting blood glucose), 2 h BG (two hours postprandial blood glucose) and HbAlc (HbAlc) were significantly lower than those before treatment (all P <0.01). Conclusion The effect of oral hypoglycemic agents on type 2 diabetes mellitus and preemptive treatment with moderate-effect insulin is significant.