论文部分内容阅读
作者对一例I型糖尿病伴有血管和眼继发症的女性患者,作了胰管阻塞式胰腺节段移植术。用Cs A—Aza—Pred作免疫抑制处理。于术后190日内度过了5次急性排斥,第4次排斥后胰岛功能显示部分障碍。移植胰于术后13日病理活检就出现严重纤维化。Gomeri染色发现B细胞在数量和质量上均有轻度损害。患者因肾病综合征于1987年7月13日死于急性肾衰和低血糖昏迷,移植胰有功能存活超过2年。作者认为多次排斥可影响胰岛功能,而移植胰和长期纤维化对胰岛的功能则影响不大,患者于死亡前发生低血糖昏迷可证实死亡时移植胰是有一定功能的。低血糖昏迷的原因复杂,可能是练合因素造成的,尚待实践进一步观察和研究。
The authors performed pancreatic segmental pancreatic segmentectomy in a female patient with type I diabetes associated with vascular and eye secondary events. Immunosuppressive treatment with Cs A-Aza-Pred. Acute rejection was performed 5 times within 190 days after surgery, and some of the islets showed dysfunction after the fourth rejection. Graft pancreas in the pathological biopsy on the 13th after a serious fibrosis. Gomeri staining found that B cells were mildly damaged in both quantity and quality. Patients died of acute renal failure and hypoglycemic coma on July 13, 1987 due to nephrotic syndrome. Transplanted pancreatic function survived for more than 2 years. The authors believe that multiple rejection can affect pancreatic islet function, and transplanted pancreatic and long-term fibrosis has little effect on pancreatic islet function, patients with hypoglycemic coma before death can confirm the death of transplanted pancreas has a certain function. The causes of hypoglycemic coma are complex and may be caused by practice factors, yet further observations and studies are yet to be made.