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目的探讨血管紧张素转换酶抑制剂(ACEI)致不良反应的特点及临床合理用药。方法选取2010年1月—2015年6月福建省武警边防总队医院收治的ACEI致不良反应的患者336例,对患者不良反应发生时间、用药情况、不良反应累及器官/系统及临床表现、治疗及转归等进行统计分析。结果 336例患者中用药当天出现不良反应21例(6.25%),用药第2天后出现不良反应315(93.75%),不良反应平均发生时间为(17.4±22.4)d;卡托普利致不良反应263例(78.27%),依那普利致不良反应32例(9.52%),贝那普利致不良反应23例(6.85%);不良反应主要累及呼吸系统,共218例(64.88%);1例患者不良反应症状控制不理想,最终死亡。结论ACEI引起不良反应的原因较多,使用时应对可能发生的不良反应进行预测,以减少不良反应的发生,保证药物的临床疗效。
Objective To investigate the characteristics of adverse reactions caused by angiotensin converting enzyme inhibitor (ACEI) and its clinical rational use. Methods From January 2010 to June 2015, 336 cases of ACEI-induced adverse reactions in Fujian Provincial Armed Police Corps Frontier Corps Hospital were selected and their adverse reaction time, medication, adverse reactions involving organ / system and clinical manifestation, treatment and Results and other statistical analysis. Results A total of 21 adverse events (6.25%) occurred in 336 patients on the day of treatment, 315 (93.75%) appeared adverse reactions after the second day of treatment, and (17.4 ± 22.4) days on average. Captopril caused adverse reactions Adverse reactions were induced by enalapril in 32 patients (9.52%) and benazepril in 23 patients (6.85%). Adverse reactions mainly involved the respiratory system, with a total of 218 cases (64.88%); One patient had adverse symptoms with poor control and eventually died. Conclusions There are many reasons for adverse reactions caused by ACEI. Prediction of possible adverse reactions should be made in order to reduce the incidence of adverse reactions and ensure the clinical efficacy of drugs.