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目的比较人乳头瘤病毒(HPV)检测、传统巴氏涂片(CPS)及薄层液基细胞学(TCT)检测在宫颈癌筛查中的应用价值。方法选取682例宫颈癌筛查者作为研究对象,对所有对象进行HPV、CPS及TCT检测,并以宫颈组织活检结果作为金标准,比较上述3种方法检测的准确性。结果 682例宫颈癌筛查者中,经组织病理学检查阳性者101例(14.81%)。HPV的阳性似然比、阴性似然比均明显高于TCT、CPS;HPV、TCT的敏感度、准确度、阴性预测值均大于CPS,HPV、CPS的特异度、阳性预测值均大于TCT,3种筛查方法的敏感度、特异度、准确度、阴性预测值比较有统计学意义(P<0.01)。结论 TCT与HPV在宫颈癌的筛查中准确性均较高,但HPV检测相对于TCT更具有可行性,适宜于在基层医院推广。
Objective To compare the value of HPV testing, traditional Pap smear (CPS) and thin-layer liquid-based cytology (TCT) detection in cervical cancer screening. Methods 682 cases of cervical cancer screening were selected as the research object, HPV, CPS and TCT were detected in all the subjects. The cervical biopsy results were used as the gold standard to compare the accuracy of the above three methods. Results Among the 682 cervical cancer screening patients, 101 (14.81%) were histopathologically positive. HPV positive likelihood ratio, negative likelihood ratio were significantly higher than the TCT, CPS; HPV, TCT sensitivity, accuracy, negative predictive value were greater than CPS, HPV, CPS specificity, positive predictive value were greater than the TCT, The sensitivity, specificity, accuracy and negative predictive value of the three screening methods were statistically significant (P <0.01). Conclusion The accuracy of TCT and HPV in screening cervical cancer is high, but the detection of HPV is more feasible than that of TCT, which is suitable for promotion in primary hospitals.