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目的 :探究结合感染T细胞斑点试验(T-SPOT.TB)应用于肺结核诊断中的价值。方法 :选取2013年1月-2015年10月兰州市肺科医院收治的35例患者作为本次研究的对象,将患者纳入试验组,另取同期收治的30例其他非肺结核呼吸系统疾病的志愿患者作为对照组。对所有患者分别进行T-SPOT.TB检测、红细胞沉降率(ESR)检测、结核抗体(TB-Ab)测定和结核菌素皮肤试验(TST),比较两组检测结果,并分析不同检测方法的敏感性与特异性。结果 :验组T-SPOT.TB检测结果阳性率为97.1%,显著高于其他3种检测方法(p<0.05);对照组T-SPOT.TB检测结果阳性率为0,显著低于其他3种检测方法(p<0.05),差异均有统计学意义;T-SPOT.TB检测的敏感度为97.1%、符合率为98.5%,均显著高于其他4种检测方法 ;特异度100%,显著高于ESR、TST,差异均有统计学意义。结论 :与传统的ESR、TB-Ab和TST检查相比,T-SPOT.TB诊断肺结核具有更高的敏感度、特异度和符合度,在该病的诊治中具有较高的应用价值。
Objective: To explore the value of T-SPOT.TB in the diagnosis of pulmonary tuberculosis. Methods: Thirty-five patients admitted to Lanzhou Pulmonary Hospital from January 2013 to October 2015 were enrolled in this study. The patients were enrolled in the trial group, and another 30 volunteers with other non-tuberculosis respiratory diseases were enrolled in the same period. Patients served as control group. T-SPOT.TB, erythrocyte sedimentation rate (ESR), tuberculosis antibody (TB-Ab) and tuberculin skin test (TST) were performed on all the patients. The results of two groups were compared and analyzed. Sensitivity and specificity. Results: The positive rate of T-SPOT.TB in test group was 97.1%, which was significantly higher than the other three methods (p <0.05). The positive rate of T-SPOT.TB in control group was 0, which was significantly lower than that of other 3 (P <0.05), the difference was statistically significant. The sensitivity of T-SPOT.TB was 97.1% and the coincidence rate was 98.5%, all of which were significantly higher than the other four detection methods; the specificity was 100% Significantly higher than ESR, TST, the differences were statistically significant. Conclusion: Compared with the traditional ESR, TB-Ab and TST examination, T-SPOT.TB diagnosis of pulmonary tuberculosis has a higher sensitivity, specificity and compliance, in the diagnosis and treatment of the disease has a high value.