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目的观察赭遂攻结汤加减治疗癌痛患者应用阿片类药物致便秘的临床疗效。方法选取泉州市中医院2016年1月—2017年1月收治的长期使用阿片类药物出现便秘的癌痛患者88例,随机分为试验组与对照组,各44例。对照组患者给予乳果糖-杜秘克等利便药治疗,试验组患者给予赭遂攻结汤加减治疗,以7 d为1个疗程,连续治疗2个疗程。比较两组患者临床疗效,治疗前后阿片类药物用量、视觉疼痛(VAS)评分、卡氏评分、胃肠道生活质量(GIQLI)评分。结果试验组患者治疗总有效率为96.7%,高于对照组的85.5%(P<0.05)。治疗前两组患者阿片类药物用量与VAS评分比较,差异无统计学意义(P>0.05);治疗后试验组患者阿片类药物用量少于对照组,VAS评分低于对照组(P<0.05)。治疗前两组患者卡氏评分与GIQLI评分比较,差异无统计学意义(P>0.05);治疗后试验组患者卡氏评分、GIQLI评分高于对照组(P<0.05)。结论赭遂攻结汤加减治疗癌痛患者应用阿片类药物致便秘的临床疗效确切,可有效改善患者临床症状,提高患者生活质量。
Objective To observe the clinical effect of ophthalmic injection of constipation treated by Omethoide Gongjie Decoction in the treatment of patients with cancer pain. Methods Eighty-eight patients with long-term opioid cancer pain who were admitted to our hospital from January 2016 to January 2017 in Quanzhou were randomly divided into test group and control group, with 44 cases in each group. Patients in the control group were treated with lactobacilli - Duke Ke and other convenient drugs, and patients in the test group were treated with Omethoide Gongjie Decoction. Seven days were given as one course of treatment and two courses of continuous treatment were given. The clinical efficacy, opioid consumption, visual acuity (VAS) score, cardiothoracic score and GIQLI score before and after treatment were compared between the two groups. Results The total effective rate of treatment in trial group was 96.7%, which was higher than that in control group (85.5%, P <0.05). There was no significant difference between the two groups before treatment and the VAS score (P> 0.05). After treatment, the amount of opioid used in the test group was less than that of the control group, and the VAS score was lower than that of the control group (P <0.05) ). There was no significant difference between the two groups before treatment and the GIQLI score (P> 0.05). After treatment, the Karnofsky scores and GIQLI scores of the test group were higher than those of the control group (P <0.05). Conclusion Ocher Suizong Jie decoction in the treatment of cancer pain patients opioid constipation clinical efficacy is exact, can effectively improve the clinical symptoms and improve patient quality of life.