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目的探讨染色体检测对恶性胸水的诊断价值。方法采用常规染色体定性检查和流式细胞术DNA定量分析检查胸腔积液中的染色体,并进行比较。结果常规染色体检查对恶性胸腔积液诊断的特异性为90.9%,敏感性为88.9%;FCM法特异性为98.9%,敏感性为90.9%;二者联合的特异性为98.6%,敏感性为88.4%。结论常规染色体检查和流式细胞术(FCM)DNA定量分析方法联合检查对胸腔积液的诊断提供了可靠的诊断依据。
Objective To investigate the diagnostic value of chromosomal detection in malignant pleural effusion. Methods Chromosomes in pleural effusion were examined by routine chromosomal qualitative tests and flow cytometry DNA quantification and compared. Results The specificity of routine chromosomal examination in diagnosis of malignant pleural effusion was 90.9%, the sensitivity was 88.9%, the specificity of FCM was 98.9% and the sensitivity was 90.9%. The combined specificity was 98.6% and the sensitivity was 88.4%. Conclusion Conventional chromosomal examination and flow cytometry (FCM) DNA quantitative analysis of combined detection of pleural effusion diagnosis provides a reliable basis for diagnosis.