论文部分内容阅读
在家兔髂股动脉血栓模型观察尿激酶（ＵＫ）和前列腺素Ｅ１（ＰＧＥ１）联合溶栓的效果。结果如下：①经导管动脉联合用药（简称联用），优于单用ＵＫ，再通率为１００％。优于常规静脉途径（再通率５０％）；②静脉联用组全身纤溶激活，即总纤溶活力增强，纤溶酶原（ＰＬＧ）和纤维蛋白降解产物（ＦＤＰ）增高。有出血的潜在危险，而动脉联用组全身纤溶改变小于静脉联用及动脉单药（ＵＫ）组。经导管动脉内联合用ＵＫ和ＰＧＥ１是一种疗效高、副作用小的溶栓方法。
The effects of urokinase (UK) and prostaglandin E1 (PGE1) combined with thrombolysis were observed in rabbit iliac artery thrombosis model. The results are as follows: ① transcatheter arterial combined therapy (referred to as combined), better than single UK, the pass rate was 100%. (50% of recanalization rate). (2) Systemic fibrinolytic activation, ie, total fibrinolytic activity, increased plasminogen (PLG) and fibrin degradation products (FDP), was superior to the conventional intravenous route. There was a potential risk of bleeding, and systemic fibrinolysis in the combination group was less than in the group with intravenous and arterial monotherapy (UK). Transcatheter arterial United UK and PGE1 is a high efficacy, small side effects of thrombolysis.