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为探讨血浆内皮素－１（ＥＴ－１）和醛固酮（Ａｌｄ）在肾病综合征患儿钠潴留中的作用，对１４例肾病综合征患儿在水肿期和消肿期的血浆ＥＴ－１、Ａｌｄ及血清渗透压、白蛋白（Ａｌｂ）、Ｎａ＋的变化进行了观测。结果显示患儿水肿期血浆ＥＴ－１比消肿期显著性升高（Ｐ＜０．０１），水肿期血浆Ａｌｄ与消肿期无明显差异（Ｐ＞０．０５）；血浆ＥＴ－１与血清Ｎａ＋呈直线正相关（ｒ＝０．４８６，Ｐ＜０．０１），与血清Ａｌｂ呈直线负相关（ｒ＝－０．４９０，Ｐ＜０．０１）。提示肾病钠潴留可能与肾排钠减少有关，ＥＴ－１在其中起了重要作用。
To investigate the role of plasma endothelin-1 (ET-1) and aldosterone (Ald) in sodium retention in children with nephrotic syndrome (NS), 14 children with nephrotic syndrome were divided into two groups: edema stage, Ald and serum osmolality, albumin (Alb), Na + changes were observed. The results showed that plasma ET-1 level in edema stage was significantly higher than that in exfoliation stage (P <0.01), there was no significant difference between plasma Ald and edema stage in edema stage (P> 0.05) Serum Na + showed a linear positive correlation (r = 0.486, P <0.01), and had a negative linear correlation with serum Alb (r = -0.490, P <0.01). Prompt renal sodium retention may be related to renal sodium decreased, ET-1 plays an important role in them.