目前肺癌已成为大城市男性恶性肿瘤发病率及死亡率的首位,早期诊断及早期治疗是遏制肺癌危害的最好方法。分子生物学的进展为肺癌早期诊断带来了希望,本文就肺癌发生的早期分子标志物的研究进展进行探讨。p16基因p16基因定位于9p21,外显子编码翻译的产物即P16蛋白能够抑制细胞 At present, lung cancer has become the first place in the morbidity and mortality of male malignancies in large cities. Early diagnosis and early treatment are the best ways to control the harm of lung cancer. Advances in molecular biology have brought hope for the early diagnosis of lung cancer. This article discusses the research progress of early molecular markers of lung cancer. The p16 gene p16 gene is located at 9p21 and the exon-encoded translocation product P16 protein is able to inhibit the cell