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重症急性胰腺炎(severe acute pancreatitis,SAP)是一种累及多系统多器官的疾病,常并发全身炎症反应综合征和多器官功能障碍综合征,严重威胁患者生命。与肺损伤和肾损伤相比,尽管SAP并发肝损伤的临床发生率较低,但SAP合并肝损伤,导致肝功能的损害,不仅加重SAP病情,还对临床治疗效果及病程和预后有着重要影响。本文就SAP并发肝脏损害的机制综述如下。
Severe acute pancreatitis (SAP) is a disease involving multiple systems and multiple organs. It often causes systemic inflammatory response syndrome and multiple organ dysfunction syndrome, which seriously threaten the life of patients. In spite of the low clinical incidence of liver injury associated with lung injury and renal injury compared with lung injury and kidney injury, SAP combined with liver injury, leading to damage to liver function, not only aggravate SAP disease, but also have an important impact on the clinical efficacy and course of disease and prognosis . This article on the mechanism of SAP complicated with liver damage are summarized below.