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本研究以放射免疫法检测了久居高原后返回平原的老人、中年人的cAMP、cGMP的血浆含量。以海拔2260m人群、作为高原对照组;以苏州地区人群,作为平原对照组。结果显示:①中度高原人cAMP与cGMP含量较平原人下降,cAMP/cGMP比值仍维持平原人水平(p>0.05),两地区老人的cAMP/cGMP比值均较中年组有所下降,但无统计学意义(P>0.05),提示:中度高原人环核苷酸呈低水平调控,缺氧是导致环核苷酸下降的重要原因;②返回平原的老人,cAMP、cGMP均增加,但以cGMP增高为主,cAMP/cGMP比值下降,和返回平原的中年组相比有显著性差异(P>0.05)。表明环核苷酸失衡,机体整个代谢加强,从而促进细胞增繁、异化率增高,细胞的免疫水平下降等,并对机体产生不利后果。
In this study, plasma levels of cAMP and cGMP were detected by radioimmunoassay in elderly and middle-aged people returning to the plains after living in the plateau. With an altitude of 2260m crowd, as a plateau control group; Suzhou population, as a plain control group. The results showed that: (1) The cAMP and cGMP levels in moderate altitude were lower than those in plain and the cAMP / cGMP ratio remained unchanged in plain population (p> 0.05). The cAMP / cGMP ratio in elderly people in both areas was lower than that in middle age group (P> 0.05), suggesting that the low level of human ring nucleotides is regulated in the plateau, hypoxia is an important reason leading to the decrease of cyclic nucleotides; ②The cAMP and cGMP in the elderly returning to the plain are increased, However, cGMP increased mainly cAMP / cGMP ratio decreased, compared with the middle-aged group returned to the plain (P> 0.05). Cyclic nucleotide imbalance shows that the body to enhance the overall metabolism, thereby promoting cell proliferation, increased rate of alienation, decreased cellular immunity, and have adverse consequences on the body.