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目的研究汉族群体海洛因成瘾与多巴胺-D2(DRD2)基因的分布规律之间的关系。方法检测DRD2基因上三个位点的多态性(启动子141c、ser311cys,和TaqI)在1000例华南汉族海洛因成瘾群体和200例对照中的分布规律。结果除启动子141c在成瘾和正常对照组分布有差异外,ser311cys、TaqI无明显差异。
Objective To study the relationship between heroin addiction and the distribution of dopamine-D2 (DRD2) gene in Chinese Han population. Methods The distribution of three polymorphisms (promoter 141c, ser311cys, and TaqI) of DRD2 gene in 1000 Han Chinese heroin addicts and 200 controls were detected. Results There were no significant differences in ser311cys and TaqI except for the promoter 141c distribution in addiction and normal controls.