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目的观察和评价卡提素注射液辅助治疗重症菌阳肺结核的疗效。方法选取初复治菌阳肺结核患者(慢性排菌病人除外)病灶总面积≥3个肺野共153例,随机分为2组。试验组(卡提素+化疗)77例,初治61例,复治16例,初治方案2SHRZ/4HR(S为链霉素,H为雷米封,R为利福平,Z为吡嗪酰胺,连用2个月;H、R连用4个月)、复治方案2SHRZE/6HRE(E为乙胺丁醇,S、H、R、Z、E连用2个月;H、R、E连用6个月),并加用卡提素注射液;对照组(单纯化疗)初治61例、复治15例,化疗方案同试验组。结果试验组和对照组疗程结束时痰菌阴转率分别为92.2%、78.9%(P<0.05);胸部X线病灶吸收好转率分别为93.5%、80.3%(P<0.05);空洞闭合率分别为87.5%、68.4%(P<0.05);2年随访,试验组无一例复发,对照组有4例(5.3%)复发。结论卡提素辅助治疗重症菌阳肺结核患者能提高痰菌阴转率,促进病灶吸收、空洞闭合,加速患者康复,远期疗效好,值得推广。
Objective To observe and evaluate the curative effect of Cardiotonics injection in the treatment of severe pulmonary infection of tuberculosis. Methods A total of 153 lung cancer cases with total area of ≥3 lung lesions were selected from patients with primary pulmonary tuberculosis (excluding patients with chronic bacteriosis), and randomly divided into two groups. In the experimental group, 77 cases were treated with kallikrein and chemotherapy, 61 cases were initially treated and 16 cases were treated by rehospitalization. The initial regimen was 2SHRZ / 4HR (S was streptomycin, H was Remy, R was rifampicin, Z was pyridine (2) H, R, E for 4 months), regimen 2SHRZE / 6HRE (E for ethambutol, S, H, R, Z, E for 2 months; H, R, E Once every 6 months), and added with Ctiamine injection; control group (chemotherapy alone) initial treatment of 61 cases, 15 cases of retreatment, chemotherapy and experimental group. Results The sputum negative conversion rates of the experimental group and the control group were 92.2% and 78.9% (P <0.05) respectively at the end of the course of treatment; the improvement rates of chest X-ray lesion absorption rate were 93.5% and 80.3% (P <0.05) Respectively, 87.5% and 68.4% respectively (P <0.05). No recurrence was observed in 2 years and 4 cases (5.3%) in the control group. Conclusions QITIU auxiliary treatment of patients with severe bronchiectasis pulmonary tuberculosis can improve sputum negative conversion rate, promote the absorption of the lesion, empty closure, accelerate the rehabilitation of patients, long-term effect is good, it is worth promoting.