糖尿病性视网膜病变(DR)是糖尿病最常见和最严重的并发症之一。目前对DR发病机制的研究多集中在蛋白质非酶糖基化终末产物的堆积、蛋白激酶C(PKC)激活、氧化应激学说、细胞因子的作用、肾素-血管紧张素及内皮素系统的异常等方面。这几种发病机制相互联系,近年来,研究人员基于这些机制进行了DR治疗药物的开发,取得了一系列的成果。 Diabetic retinopathy (DR) is one of the most common and serious complications of diabetes. At present, most of the studies on the pathogenesis of DR focus on the accumulation of non-enzymatic glycation end products, protein kinase C (PKC) activation, oxidative stress, cytokines, renin-angiotensin and endothelin system Abnormal and so on. These pathogenesis are interrelated. In recent years, researchers have developed DR therapeutic drugs based on these mechanisms and have achieved a series of results.