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目的:探讨屏氧酶1(PONl)A/B192基因型与脑梗死及脑梗死类型的关系。方法:急性脑梗死病人共131例,对照组非心脑血管病人群339例。采用改良的聚合酶链式反应(限制性片段长度多态性方法进行PONIA/B192基因型测定,比较各基因型的分布。结果:动脉粥样硬化血栓性脑梗死的基因型分布与对照组有差异,BB型(58%)明显高于对照组(40%),并且有统计学意义(P<0.05)。结论:PONI192BB型可能与动脉粥样硬化血栓性脑梗死的发生相关。
Objective: To investigate the relationship between PON1 A / B192 genotype and cerebral infarction and cerebral infarction types. Methods: A total of 131 patients with acute cerebral infarction, 339 non-cardiovascular and cerebrovascular patients in the control group. The genotypes of PONIA / B192 were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and genotype distribution was compared.Results: The genotype distribution of atherothrombotic cerebral infarction was (P <0.05) .Conclusion: PONI192BB may be related to the occurrence of atherothrombotic cerebral infarction.