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目的:通过血管内超声-虚拟组织学(intravascular ultrasound-virtual histology,IVUS-VH)技术探讨急性冠状动脉综合征(ACS)和稳定型心绞痛(SA)患者冠状动脉病变的影像特点,并探讨易损斑块的性质及其临床相关性。方法:对32例ACS患者冠状动脉进行IVUS-VH研究,与30例SA患者比较,分析两者斑块的性质及其与临床血脂水平的相关性。结果:ACS患者易损斑块发生率显著高于SA患者(36.7%∶14.5%,P<0.05),斑块组成以纤维脂肪组织和坏死成分为主,而SA患者斑块纤维成分和钙化成分较高。2组中纤维脂肪组织与血低密度脂蛋白水平呈正相关(r=0.08,P<0.05),与高密度脂蛋白水平呈负相关(r=-0.06,P<0.05)。结论:ACS患者易损斑块发生率明显高于SA患者,且斑块成分不同,与临床血脂水平具有相关性。
Objective: To investigate the characteristics of coronary artery lesions in patients with acute coronary syndrome (ACS) and stable angina pectoris (SA) by intravascular ultrasound-virtual histology (IVUS-VH) The nature of the plaque and its clinical relevance. Methods: The coronary arteries of 32 patients with ACS were studied by IVUS-VH. Compared with 30 patients with SA, the plaque characteristics and their relationship with clinical serum lipid levels were analyzed. Results: The incidence of vulnerable plaques in patients with ACS was significantly higher than that in patients with SA (36.7% vs14.5%, P <0.05). The plaque composition was predominantly fibrotic tissue and necrotic components, while the plaque fiber components and calcification components Higher. There was a positive correlation between fibrous adipose tissue and blood LDL level (r = 0.08, P <0.05) and a negative correlation with HDL level (r = -0.06, P <0.05). Conclusion: The incidence of vulnerable plaque in patients with ACS is significantly higher than that in patients with SA, and the plaque components are different, which is correlated with the level of clinical blood lipid.