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本文采用免疫组化方法用纤维连接蛋白 (fibronectin,FN) ,层粘连蛋白 (laminin,L N) ,和 型胶原 (collagenIV,Col.IV)抗体对 5 4例鼻咽癌及 1例鼻咽鳞状上皮瘤的基底膜进行了研究。结果显示鼻咽鳞状上皮瘤中的基底膜呈连续线状 ,而鼻咽癌的癌巢周围基底膜通常是不完整的 ,呈断续甚至消失的改变。高分化鳞癌显示连续线状基膜 ,偶有中断。低分化腺癌则显示断续不完整的基膜 ,大圆型细胞癌、低分化鳞癌部分显示连续线状基膜 ,偶有中断。未分化癌的基膜显示断线和消失的改变 ,癌瘤中基底膜的分布情况与癌实质类型、间质结构以及间质中淋巴细胞、浆细胞数量、嗜银纤维分布类型有关。
In this study, 54 cases of nasopharyngeal carcinoma and 1 case of nasopharyngeal squamous cell carcinoma were treated with immunohistochemistry with fibronectin (FN), laminin (LN) and collagenIV (Col.IV) The epithelial tumor of the basement membrane was studied. The results showed that the basement membrane of nasopharyngeal squamous cell carcinoma was continuous linear, while the basement membrane around the cancer nest of nasopharyngeal carcinoma is usually incomplete, showing intermittent or even disappear changes. Well-differentiated squamous cell carcinoma showed continuous linear basement membrane, occasionally interrupted. Poorly differentiated adenocarcinoma showed intermittent incomplete basement membrane, large round cell carcinoma, poorly differentiated squamous cell carcinoma showed part of a continuous linear basement membrane, occasionally interrupted. The basal lamina of undifferentiated carcinoma showed the changes of the broken and disappearing. The distribution of the basilar membrane in carcinoma was related to the type of carcinoma, the interstitial structure and the number of lymphocytes, plasma cells and type of argyrophilic fiber in the stroma.