Backrround There is little information on the factors that have influenced the long-term success rate of radiofrequency ablation of ventricular arrhythmias (VAs) at different targets.The objective of this study was to investigate the characteristics of the ablation of VAs and the factors influencing the long-term success rate in our center.Methods Totally,2751 consecutive patients (mean ages 4415 years,male/female 58.6％/41.4％) with VAs underwent radiofrequency ablation in Guangdong Provincial People’s Hospital from 2013 to 2018 were analyzed.Baseline data were retrieved from the medical record system.Long-term follow-up data were obtained by telephone interview.We mainly recorded the patient’s last post-ablation holter,and the symptoms after ablation.Multivariable regressions were applied to assess the relationship between the long-term success rate and the influence factors.Results Through the baseline data of 2751 patients,we found that the acute success rate of ablation was 95.1％.The average follow-up time was 16±5 months (ranging from 1 to 80).In all,304 patients (11％) lost follow-up,while 2447 patients (89％) were successfully followed.The long-term success rate of ablation was 82.56％.By means of multivariable regression analyses,it was discovered that cardiovascular diseases,such as coronary heart disease (OR: 0.568,95％ CI: 0.327-0.987),hypertension (OR: 1.554,95％ CI: 1.100-2.198),were independently associated with the long-term success rate,as well as ablation approaches (OR: 0.212,95％ CI: 0.082-0.550).Lower ablation success rates of the patients whose VAs were originated from some uncommon region,like left ventricular papillary muscle,Summit,etc.were observed.Conclusions Ablation approaches,concomitant cardiovascular diseases,and ablation targets were related to the long-term clinical outcome of VAs ablation.