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血小板活性与动脉硬化性心脏病密切相关。在不稳定型心绞痛和急性心肌梗塞(AMI)发病机理中,血栓形成是一重要因素,而血栓素A_2(TXA_2)和前列环素(PGI_2)又是血栓形成的重要病理生理因素。本文报道间断阿斯匹林(ASA)治疗AMI对体内TXA_2和PGI_2生成的影响。材料和方法连续研究20例AMI患者,梗塞前7天内均未使用过阿斯匹林(ASA)或其它环氧化酶抑制剂。症状发作至入院时间
Platelet activity and arteriosclerotic heart disease are closely related. Thrombosis is an important factor in the pathogenesis of unstable angina and acute myocardial infarction (AMI), and thromboxane A_2 (TXA_2) and prostacyclin (PGI_2) are important pathophysiological factors of thrombosis. This article reports the effects of intermittent aspirin (ASA) treatment of AMI on TXA2 and PGI2 production in vivo. MATERIALS AND METHODS Continuous study of 20 patients with AMI who had not used aspirin (ASA) or other cyclooxygenase inhibitors within 7 days prior to infarction. Symptom onset to admission time