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研究原发性癫痫患者血浆和脑脊液（ＣＳＦ） 中阿片肽含量变化及其临床意义。对正常对照组和原发性癫痫患者于发作间歇期，同时采ＣＳＦ 和静脉血， 用放射免疫法测定其β内啡肽（βＥＰ）、亮氨酸脑啡肽（ＬＥＫ） 和强啡肽（ＤｙｎＡ１ ～１３） 的含量。结果表明， 与对照组相比， 癫痫组血浆和ＣＳＦ中βＥＰ含量无显著变化，ＬＥＫ 含量显著增高；ＣＳＦ 中ＤｙｎＡ１ ～１３ 含量无显著变化， 血浆中Ｄｙｎ Ａ１ ～１３ 含量显著增高。本文作者认为，阿片肽参与原发性癫痫发生与发展的病理生理过程。
To study the changes of opioid peptide in plasma and cerebrospinal fluid (CSF) of patients with primary epilepsy and its clinical significance. The normal control group and the patients with primary epilepsy were intermissioned with CSF and venous blood at the same time. The levels of βEP, LEK and dynorphin (LEK) were measured by radioimmunoassay DynA1 ~ 13) content. The results showed that compared with the control group, there was no significant change in plasma and CSF levels of epilepsy, LEK content was significantly increased; DynA1 ~ 13 content did not change significantly, plasma Dyn A1 ~ 13 content was significantly increased. The authors believe that opioid peptide is involved in the pathophysiology of primary epileptogenesis and development.