论文部分内容阅读
目的探讨老年高血压患者血尿酸水平与颈动脉粥样硬化的相关性。方法测定60例老年高血压患者颈总动脉平均内中膜厚度(IMT)、尿酸与空腹血糖、甘油三酯(TG)、胆固醇(TC)水平,按颈总动脉的平均IMT将患者分为内膜正常组、内膜增厚组、斑块形成组,比较各组间尿酸水平,对颈总动脉内膜异常患者,采用多元回归分析,统计颈总动脉IMT和尿酸、空腹血糖、TG、TC之间的关系。结果内膜正常组、内膜增厚组、斑块形成组血尿酸水平分别为(277±51)、(313±46)、(365±47)μmol/L,3组间比较差异有统计学意义(P<0.001),动脉硬化组中颈总动脉IMT与尿酸、TG呈正相关(R=0.6478,P<0.01)。结论老年高血压患者颈总动脉平均IMT与尿酸呈正相关,提示血尿酸升高是颈总动脉粥样硬化的危险因素。
Objective To investigate the relationship between serum uric acid level and carotid atherosclerosis in elderly patients with hypertension. Methods The mean intima-media thickness (IMT), uric acid, fasting blood glucose, triglyceride (TG) and cholesterol (TC) were measured in 60 elderly hypertensive patients. The patients were divided into two groups according to the average IMT of common carotid artery Normal group, intimal thickening group and plaque formation group. The level of uric acid in each group was compared. Multiple regression analysis was used to analyze common carotid artery IMT, uric acid, fasting blood glucose, TG, TC The relationship between. Results The levels of serum uric acid were (277 ± 51), (313 ± 46) and (365 ± 47) μmol / L in normal endometrium, endometrial thickening group and plaque formation group, respectively. The differences among the three groups were statistically significant (P <0.001). There was a positive correlation between carotid artery IMT and uric acid and TG in arteriosclerosis group (R = 0.6478, P <0.01). Conclusion The average carotid artery IMT in elderly patients with hypertension is positively correlated with uric acid, suggesting that elevated serum uric acid is a risk factor for common carotid artery atherosclerosis.