氟尿嘧啶类药物作为放射治疗增敏剂用于临床放化疗已取得良好的效果 ,特别是对腹部恶性肿瘤。氟铁龙是 5 氟尿嘧啶的前体药物 ,具有肿瘤靶向性 ,在肿瘤中的浓度较高 ,且可通过口服用药 ,可作为较好的放射增敏剂。目前已报道口服氟铁龙对胰腺癌、肝癌、直肠癌的放射增敏作用 ,本文介绍其放射增敏机制、临床前期的实验研究、临床放射增敏及展望。 As a radiation therapy sensitizer, fluorouracils have been used for clinical radiotherapy and chemotherapy. Good results have been achieved, especially for malignant tumors of the abdomen. Diflurane is a prodrug of 5-fluorouracil with tumor targeting, high concentration in tumors, and can be used as oral radiopharmaceutical. The radiosensitization of pantothecin, liver cancer, and rectal cancer has been reported so far. This article describes its radiosensitization mechanism, preclinical experimental studies, clinical radiosensitization and prospects.