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目的:探讨丹参多酚酸盐治疗急性脑梗死患者血清C反应蛋白水平和血液流变学的影响并探讨其与的临床疗效的关系。方法:120例发病在72h内的急性脑梗死患者,随机分为两组,治疗组予以常规措施并加治疗丹参多酚酸盐,对照组仅用常规治疗。观察治疗前后血清CRP水平和血液流变学的变化。结果:两组治疗后血清hs-CRP浓度较治疗前有明显降低(P<0.05),但治疗组降低较对照组更显著;治疗组血液流变学指标均有明显改善,与治疗前比较具有显著性。结论:丹参多酚酸盐治疗急性脑梗死有效,可能与改善血液流变学、降低血清C反应蛋白水平有关。
OBJECTIVE: To investigate the effect of salvianolate on serum C-reactive protein and hemorheology in patients with acute cerebral infarction and explore its relationship with clinical efficacy. Methods: A total of 120 patients with acute cerebral infarction within 72 hours were randomly divided into two groups. The treatment group was given routine treatment and plus Salvia miltiorrhiza polyphenols, while the control group was treated only routinely. The changes of serum CRP level and hemorheology before and after treatment were observed. Results: The serum concentration of hs-CRP in both groups after treatment was significantly lower than that before treatment (P <0.05), but the reduction in treatment group was more significant than that in control group. The indexes of hemorheology in treatment group were significantly improved, compared with those before treatment Significance. Conclusion: Salvianolate is effective in the treatment of acute cerebral infarction, which may be related to improvement of hemorheology and reduction of serum C-reactive protein.