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Ⅰ.体外研究目前一般认为,机体对血吸虫的免疫主要是针对皮肤内的早期童虫,而不是在门脉寄生的成虫。现有的研究结果表明,血吸虫童虫的皮层对宿主的免疫攻击起着靶子的作用。有关血吸虫童虫的杀伤机制,首次由Clegg等(1972)提出,他们证明,当培养液中含有曼氏血吸虫免疫的罗猴血清时,曼氏血吸虫早期童虫在体外培养后4天被杀死,起作用的抗体为IgG类,似乎是补体依赖的。Perez等(1973)用来自感染曼氏血吸虫的罗猴的抗体和细胞首次证明抗体和细胞对血吸虫的杀伤有协同作用,即抗体依赖的细胞介导的细胞毒性作用(ADCC)。Butterwo-
I. In vitro studies It is generally believed that the body’s immunity to schistosomes is mainly directed against early stage schistosomiasis in the skin rather than adult parasitized in the portal vein. The existing results show that the cortical layer of Schistosoma japonicum plays a target role in host immune challenge. For the first time, Clegg et al. (1972) suggested that the killing mechanism of Schistosoma japonicum Schistosoma japonicum was killed 4 days after in vitro culture when the culture contained rhesus monkey serum immunized with Schistosoma mansoni The active antibody is of the IgG class and appears to be complement-dependent. Perez et al. (1973) used antibodies and cells from rhesus monkeys infected with Schistosoma mansoni for the first time to demonstrate a synergistic effect of antibodies and cells killing schistosomes, namely antibody-dependent cell-mediated cytotoxicity (ADCC). Butterwo-