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为进一步研究β－内啡肽在创伤中的变化规律，笔者制成狗颅脑火器伤和狗后肢火器伤模型，并采用放射免疫法测定动物血浆、脑脊液、下丘脑及垂体中β－内啡肽含量。结果发现颅脑火器伤组伤后血浆、脑脊液中β－内啡肽含量明显升高，垂体和下丘脑中含量减少；后肢伴骨折的贯通伤组伤后血浆、脑脊液、垂体和下丘脑中β－内啡肽含量均明显升高。结果提示：在创伤中只要伤情达到一定的严重程度，就可引起β－内啡肽含量的变化，不同部位的损伤，其变化的时相亦不同
To further study the changes of β-endorphin in trauma, the author made a model of craniocerebral gunshot wounds and firearm injuries of hindlimbs in dogs. The β-endorphins in plasma, cerebrospinal fluid, hypothalamus and pituitary were determined by radioimmunoassay Peptide content. The results showed that the contents of β-endorphin in plasma and cerebrospinal fluid were significantly increased and the contents of pituitary and hypothalamus were decreased in craniocerebral firearm injury group. The levels of β-endorphin in plasma, cerebrospinal fluid, pituitary and hypothalamus - Endorphin levels were significantly increased. The results suggest that as long as the injury reaches a certain severity in the trauma, the content of β-endorphin may change, and the damage of different parts may also change in different phases