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口服缓释制剂的使用不仅可减少药物的服用次数,而且可维持较低的血药浓度,降低药物的毒性和副作用。但口服制剂常受胃排空速率的影响,致使十二指肠、小肠上段等药物主要吸收部位不能长时间、有效地吸收药物。因此,即使药物的释放速率恒定,药物被吸收入血的能力也不强,难以得到恒定的、理想的血药浓度。本文介绍一种能滞留在胃内的漂浮型缓释胶囊剂,它与其它类型的漂浮制剂(如大直径的多孔性胶囊或片剂,亲水胶制剂,空心制剂,小水泡型胶囊剂)相比较,具有制备简单、成本低廉等优点。该缓释胶囊的比重小于1,而胃液的比重为1.004～
The use of oral sustained-release preparations not only reduces the number of doses of the drug, but also maintains a lower plasma concentration and reduces the toxicity and side effects of the drug. However, oral formulations often affected by the rate of gastric emptying, resulting in the duodenum, upper intestine and other drugs can not absorb the main part of the long-term, effective absorption of drugs. Therefore, even if the release rate of the drug is constant, the drug’s ability to be absorbed into the blood is not strong enough to obtain a constant and ideal plasma concentration. This article describes a floating sustained release capsule that can remain in the stomach and is compatible with other types of floating preparations such as large diameter porous capsules or tablets, hydrophilic gel formulations, hollow formulations, and small blister packs. Compared with the preparation of simple, low cost and so on. The specific gravity of the sustained release capsules is less than 1, while the specific gravity of gastric juice is 1.004 ~