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应用中医外治理论，自制痛膜宁贴剂，利用Ｋ￣＋致痛动物模型观察了动物应用药膜前后挣扎反应及其血浆、脑匀浆中β－内啡肽放免活性（β－ＥＰ－ｉｒ）的变化。实验结果表明，在外贴痛膜宁制剂后，动物在致痛过程中挣扎反应的次数明显减少，血浆及海马、下丘脑的β－ＥＰ含量明显升高，提示痛膜宁贴剂外用具有显著的镇痛效应，后者与动员内源性阿片肽机制有关。
The application of traditional Chinese medicine treatment theory, self-made painkillers Ning patch, the use of K ~ + animal model of pain induced by animals before and after the application of membrane reaction and the plasma, brain homogenate β-endorphin radioactivity (β-EP- ir) changes. The experimental results showed that the number of struggling animals in the process of induced pain was significantly decreased, and the content of β-EP in plasma, hippocampus and hypothalamus was significantly increased, Analgesic effect, the latter with the mobilization of endogenous opioid peptide mechanism.