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目的:探讨鼻咽癌组织中HSP70和HSP90β的表达及其与组织分级、预后之间的关系。方法:应用免疫组织化学SP法分别检测50例鼻咽癌组织中HSP70和HSP90β的表达情况,并分析二者表达与鼻咽癌临床与预后的关系。另取10例鼻咽部正常组织作为正常对照。结果:鼻咽癌中HSP70和HSP90β阳性率高于正常组织,而且鼻咽癌分化程度越低,HSP70和HSP90β的表达越强;HSP90β和HSP70阴性表达者5年生存率明显高于阳性者(P<0.05)。结论:HSP90β和HSP70的过度表达与鼻咽癌的发生、发展以及预后有关。
Objective: To investigate the expression of HSP70 and HSP90β in nasopharyngeal carcinoma and its relationship with the histological grade and prognosis. Methods: The expression of HSP70 and HSP90β in 50 cases of nasopharyngeal carcinoma were detected by immunohistochemical SP method. The relationship between the expression of HSP70 and HSP90β and the clinical and prognosis of NPC were analyzed. Another 10 cases of nasopharyngeal normal tissue as a normal control. Results: The positive rates of HSP70 and HSP90β in nasopharyngeal carcinoma were higher than those in normal tissues, and the lower the differentiation degree was, the stronger the expression of HSP70 and HSP90β were. The 5-year survival rates of HSP90β and HSP70 negative were significantly higher than those of normal <0.05). Conclusion: The overexpression of HSP90β and HSP70 is related to the occurrence, development and prognosis of nasopharyngeal carcinoma.