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1946年Robert Wilson首次提出可将质子线用于临床治疗,由于技术复杂,只有少数国家进行了研究。到1986年,世界上已有美国,瑞典、苏联、日本和瑞士等5个国家9个实验室在临床上共试治了5000多位病人,并取得了较好的效果。世界上第一台医用250MeV质子同步加速器(Synchrotron)已于1990年10月在美国加州罗马林达大学医学中心开始临床治疗。带电重粒子(如质子)在介质的射程中,开始时百分深度量曲线较平坦,但在将达终点时有一个急骤上升的Bragg峰,然后骤降为零(图1)。在单能射线中,此峰
In 1946, Robert Wilson proposed for the first time that proton lines could be used for clinical treatment. Because of complicated technology, only a few countries have conducted research. By 1986, nine laboratories in five countries including the United States, Sweden, the Soviet Union, Japan, and Switzerland had clinically tested more than 5,000 patients and achieved good results. The world’s first medical 250 MeV proton synchrotron (Synchrotron) began clinical treatment in October 1990 at the University of California, Lindlin University Medical Center. When the charged heavy particles (such as protons) in the medium range, the percent depth curve at the beginning is relatively flat, but there will be a sharply rising Bragg peak at the end point, and then it will drop to zero (Figure 1). In single-energy rays, this peak