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卵巢纤维化严重威胁女性生殖健康和生活质量,是造成卵巢功能衰退的原因之一。转化生长因子β1、结缔组织生长因子、血管内皮生长因子、缩血管性细胞因子等生长因子是刺激卵巢组织发生纤维化的主要因素。纤维化的表现可出现在放化疗后、卵巢早衰、糖尿病以及多囊卵巢综合症的卵巢组织中。本文就卵巢纤维化及其影响因素,以及卵巢纤维化的相关疾病作一简要介绍。
Ovarian fibrosis, a serious threat to women’s reproductive health and quality of life, is one of the reasons for the decline of ovarian function. Transforming growth factor β1, connective tissue growth factor, vascular endothelial growth factor, vasoconstrictors and other growth factors are the main factors that stimulate the occurrence of fibrosis in ovarian tissue. Fibrosis may occur after chemoradiation, premature ovarian failure, diabetes and polycystic ovary syndrome in ovarian tissue. This article on ovarian fibrosis and its influencing factors, as well as related diseases of ovarian fibrosis make a brief introduction.