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目的:研究美沙拉嗪颗粒联合美常安胶囊治疗溃疡性结肠炎的临床疗效及对炎症反应的影响。方法:选取本院自2015年1月至2016年1月收治的92例轻、中度溃疡性结肠炎患者,随机分为对照组和治疗组各46例。对照组单独行美沙拉嗪颗粒治疗,治疗组行美沙拉嗪颗粒联合美常安胶囊治疗,总疗程16周。对比观察两组患者治疗后对临床症状、临床症状积分、有效率以及炎症指标的改变。结果:治疗组患者的症状改善情况、总有效率均显著高于对照组(P<0.05),治疗组术前术后临床症状评分也明显优于对照组(P<0.05);两组患者治疗后红细胞沉降率(ESR)和C-反应蛋白(CRP)均明显降低,且治疗组降低更显著,差异有统计学意义(P<0.05)。结论:美沙拉嗪颗粒联合美常安胶囊可有效提高轻、中度溃疡性结肠炎治疗效果,减轻炎症反应,改善患者临床症状,临床效果显著,值得推广和应用。
Objective: To study the clinical efficacy of mesalazine granules combined with Meichangan capsule in the treatment of ulcerative colitis and its effect on inflammatory reaction. Methods: A total of 92 patients with mild to moderate ulcerative colitis admitted to our hospital from January 2015 to January 2016 were randomly divided into control group and treatment group, with 46 cases in each group. The control group was treated with mesalazine alone. The treatment group was treated with mesalamine granules and Mei Chang An Capsule for 16 weeks. Compare the two groups of patients after treatment of clinical symptoms, clinical symptom score, effective rate and changes in inflammatory markers. Results: The symptom improvement rate and total effective rate in the treatment group were significantly higher than those in the control group (P <0.05), and the clinical symptom scores in the treatment group were also significantly better than those in the control group (P <0.05) The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were significantly decreased, and the treatment group decreased more significantly, the difference was statistically significant (P <0.05). Conclusion: Mesalazine granules combined with Meichangan capsule can effectively improve the curative effect of light and moderate ulcerative colitis, relieve inflammatory reaction and improve the clinical symptoms of patients. The clinical effect is worthy of popularization and application.