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目的探讨肺癌、肺部感染患者血清抗核抗体(ANA)谱、类风湿因子(RF)的表现特点。方法采用免疫印迹法检测抗核抗体谱,免疫散射比浊法检测类风湿因子,对照分析90例肺癌患者(均经病理组织学或细胞学检查确诊)、100例肺部感染患者及36例健康人血清抗核抗体谱、类风湿因子的表现特点。结果肺癌患者ANA谱阳性率显著高于健康人群,60岁以上老年肺癌患者ANA谱阳性率显著高于同年龄段健康人群及肺部感染患者,同时,60岁以上老年肺癌患者ANA谱阳性率显著高于60岁以下肺癌患者。肺部感染患者ANA谱阳性率在各年龄组间无明显差异,虽然数据表明随年龄增大阳性率增高,但未取得统计学数据支持。RF阳性率各年龄段无明显差异,肺癌患者与肺部感染患者及健康人群相比,亦无明显差异。结论肺癌与抗核抗体谱有关,肺部感染无明显相关。
Objective To investigate the characteristics of serum anti-nuclear antibody (ANA) and rheumatoid factor (RF) in patients with lung cancer and lung infection. Methods The anti-nuclear antibody spectrum was detected by immunoblotting and rheumatoid factor by immunostaining turbidimetry. 90 patients with lung cancer were confirmed by histopathology and cytology, 100 patients with pulmonary infection and 36 healthy controls Human serum anti-nuclear antibody spectrum, rheumatoid factor performance characteristics. Results The positive rate of ANA in patients with lung cancer was significantly higher than that in healthy people. The positive rate of ANA in elderly patients with lung cancer over 60 years old was significantly higher than that in healthy people and patients with lung infection in the same age group. Meanwhile, the positive rate of ANA in elderly patients with lung cancer over 60 years old was significantly More than 60 years of age lung cancer patients. The positive rate of ANA in patients with pulmonary infection was not significantly different among all age groups. Although the data showed that the positive rate of ANA increased with age, no statistical data was obtained. There was no significant difference in RF positive rate among all age groups. There was no significant difference between lung cancer patients and those with lung infection and healthy people. Conclusion Lung cancer is related to antinuclear antibody spectrum, but no significant correlation between pulmonary infection and lung cancer.