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当注入人体的大输液中含有热原的量达1μg/kg以上时,就可引起热原反应。轻者出现寒战、发热,重者恶心、呕吐,甚至发生休克而死亡。如何控制大输液中含热原的限度,我国药典中规定了“热原检查法”,本法系将一定剂量的供试品,静脉注入家兔体内,在规定时间内,观察家兔体温升高的情况,以判定供试品中所含热原的限度是否符合规定。这里指用家兔体温升高的情况,来判断供试品中所含热原的限度是否合格,然而,在实际检测中常会遇到家兔体温降低的现象。本文作者通过多年实践经验,统计分析了家兔体温下降的原因并提出了相应处理措施。
When the infusion into the human body contains pyrogen in the amount of 1μg / kg or more, can cause pyrogen reaction. Light chills, fever, severe nausea, vomiting, and even death and death. How to control the limit of pyrogen in large transfusion, China’s Pharmacopoeia provides “pyrogen test method”, this law will be a dose of the test sample, intravenous injection of rabbits in vivo, observed within a predetermined period of body temperature rise High, in order to determine the pyrogen contained in the test limit is consistent with the provisions. This refers to the use of rabbits increased body temperature to determine the pyrogen content of the test contained in the limits of eligibility, however, often encountered in the actual test rabbit body temperature decreased phenomenon. Through years of practical experience, the author of the paper statistically analyzed the reasons for the decrease of body temperature in rabbits and proposed corresponding measures.