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目的:观察冠脉宁通方对不稳定型心绞痛近期危险事件的预防作用。方法:将入选的不稳定型心绞痛患者参考发病季节,按区组随机化分组法分为治疗组(30例)与对照组(30例)。对照组给予西医常规治疗,治疗组在对照组治疗基础上加用中药冠脉宁通方汤剂内服。经治疗观察1个月,记录近期危险事件和治疗前后量化积分,采用尼莫地平法评定疗效。经比较,两组危险事件发生情况和疗效均存在显著统计学差异(P<0.01)。结论:冠脉宁通方对不稳定型心绞痛近期危险事件的预防作用显著,优于西医常规治疗,未发现不良事件,值得临床推广。
Objective: To observe the preventive effect of “Guanni Ning Tong Fang” on the recent dangerous events in patients with unstable angina pectoris. Methods: The patients with unstable angina pectoris were divided into the treatment group (30 cases) and the control group (30 cases) according to the season of onset according to the block randomization method. The control group was given routine treatment of Western medicine. The treatment group was treated with Guanmaining Tongtong Decoction orally on the basis of the control group. After treatment for 1 month, the recent dangerous events were recorded and quantified before and after treatment. Nimodipine was used to evaluate the curative effect. By comparison, there was a significant statistical difference between the two groups in the occurrence of the risk events and the curative effect (P <0.01). Conclusion: Guanmai Ningtong Fang has a significant preventive effect on recent dangerous events in patients with unstable angina, which is superior to routine treatment of western medicine. No adverse events are found, which is worthy of clinical promotion.