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目的:评估布拉酵母菌对婴幼儿急性腹泻病的临床疗效。方法:以我院儿科门诊年龄1个月~3岁、大便次数>3次/天、镜检大便白细胞<10个/高倍镜视野的婴幼儿急性腹泻病患儿76例为研究对象,随机分为治疗组和对照组各38例,两组均给予常规对症支持治疗,治疗组加服布拉酵母菌散剂,≤1岁每次250 mg,1次/天,>1岁每次250 mg,2次/天,治疗5 d后判断疗效。结果:治疗组总有效率94.7%,高于对照组的76.3%(P<0.01)。大便次数第3天治疗组为(2.13±1.22)次/天,对照组为(4.93±1.62)次/天;治疗第5天治疗组(1.65±0.52)次/天,对照组(2.12±0.96)次/天(P<0.01)。大便性状恢复正常时间治疗组为(2.99±0.25)d,对照组为(4.32±1.04)d(P<0.01);腹泻缓解时间治疗组为(3.82±0.26)d,对照组为(4.43±0.43)d(P<0.01)。结论:布拉酵母菌治疗婴幼儿急性腹泻病效果良好,且未发现明显不良反应,值得临床推广应用。
OBJECTIVE: To evaluate the clinical efficacy of S. cerevisiae in the treatment of acute diarrhea in infants and young children. Methods: A total of 76 infantile acute diarrhea patients aged from 1 month to 3 years old with pediatric outpatient department in our hospital, stool frequency> 3 times / day, microscopic examination of stool leukocytes <10 / high magnification were randomly divided For the treatment group and the control group of 38 cases, the two groups were given conventional symptomatic and supportive treatment, the treatment group with service yeast powder, ≤ 1 year old each 250 mg, 1 time / day,> 1 year old each 250 mg, 2 times / day, 5 days after treatment to determine the efficacy. Results: The total effective rate was 94.7% in the treatment group, which was higher than 76.3% in the control group (P <0.01). The stool frequency in the third day was (2.13 ± 1.22) days in the control group and (4.93 ± 1.62) days in the control group, and (1.65 ± 0.52) in the fifth day and 2.12 ± 0.96 in the control group ) Times / day (P <0.01). The average recovery time of stool was (2.99 ± 0.25) days in the treatment group and (4.32 ± 1.04) days in the control group (3.82 ± 0.26) days and 4.43 ± 0.43 days in the control group ) d (P <0.01). Conclusion: The results showed that Bhola yeast was effective in treating acute diarrhea in infants and young children, and no obvious adverse reactions were found. It is worthy of clinical application.