目的探讨ω-3多不饱和脂肪酸对急性肺损伤(ALI)疗效。方法选择ALI患者39例,随机分为2组。对照组(19例)予以常规治疗,治疗组20例在常规治疗基础上加用ω-3多不饱和脂肪酸。对比2组治疗有效率及治疗后2、4和8 d的血气分析变化观察氧分压、氧合指数等的变化。结果治疗组有效率为70%,与对照组31.6%相比差异有统计学意义(P<0.05);治疗组PaO2、氧合指数高于对照组,同时心率、乳酸水平,下降较对照组明显,差异有统计学意义(P<0.05),特别是乳酸(P<0.01)。结论ω-3多不饱和脂肪酸应用有助于改善ALI患者的呼吸功能及预后。 Objective To investigate the therapeutic effect of ω-3 polyunsaturated fatty acids on acute lung injury (ALI). Methods 39 patients with ALI were randomly divided into two groups. The control group (n = 19) was given routine treatment. 20 cases in the treatment group were given omega-3 polyunsaturated fatty acids on the basis of routine treatment. The changes of oxygen partial pressure, oxygenation index and other changes were compared between the two groups in the treatment efficiency and blood gas changes at 2, 4 and 8 days after treatment. Results The effective rate of the treatment group was 70%, which was significantly different from that of the control group (31.6%, P <0.05). The PaO2 and oxygenation index of the treatment group were higher than those of the control group, meanwhile, heart rate and lactate level decreased significantly , The difference was statistically significant (P <0.05), especially lactic acid (P <0.01). Conclusion The application of ω-3 polyunsaturated fatty acids can improve the respiratory function and prognosis of patients with ALI.