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目的探讨直肠癌淋巴结转移与临床病理特征及术后生存时间之间的关系。方法分析67例行全直肠系膜切除术患者的性别、年龄、肿瘤原发灶大小、大体类型、浸润深度、组织学类型、分化程度及术前血清癌胚抗原(CEA)水平与术后淋巴结病检转移情况及与生存时间的关系。结果单因素分析结果发现,肿瘤大小、大体类型、浸润深度、组织学类型、分化程度与淋巴结转移相关;进一步多因素分析结果提示,组织学类型、分化程度与淋巴结转移相关。全组5年生存率为59.7%;无淋巴结转移组预后好于有淋巴结转移组,两生存曲线比较差异有统计学意义(χ2=13.658,P=0.000)。结论直肠癌组织学类型和分化程度是淋巴结转移的主要危险因素,根据患者临床病理特征和淋巴结转移之间的相关性能够更准确诊断病情、制定治疗方案以及判断预后。
Objective To investigate the relationship between lymph node metastasis and clinicopathological features and survival time in patients with rectal cancer. Methods The clinical data of 67 patients who underwent total mesorectal excision were retrospectively analyzed, including gender, age, size of primary tumor, gross type, depth of invasion, histological type, differentiation, preoperative serum CEA and postoperative lymphadenopathy Check the transfer and the relationship with the survival time. Results The results of univariate analysis showed that tumor size, gross type, depth of invasion, histological type and differentiation were correlated with lymph node metastasis. Further multivariate analysis indicated that the histological type and the degree of differentiation correlated with lymph node metastasis. The overall 5-year survival rate was 59.7%. The prognosis of patients without lymph node metastasis was better than that with lymph node metastasis. There was significant difference between the two survival curves (χ2 = 13.658, P = 0.000). Conclusion The histological type and differentiation of rectal cancer are the main risk factors of lymph node metastasis. According to the correlation between clinicopathological features and lymph node metastasis, the diagnosis of rectal cancer can diagnose the disease more accurately, make the treatment plan and judge the prognosis.