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目的评价我国人群基质金属蛋白酶-9(MMP-9)基因C-1562T多态性与缺血性脑卒中的关系。方法对2015年11月前公开发表的关于中国人缺血性脑卒中MMP-9基因C-1562T多态性的病例对照研究进行Meta分析。结果共纳入8个病例对照研究。Meta分析结果表明,MMP-9基因C-1562T多态性与中国人缺血性脑卒中的发病相关,差异有统计学意义(等位基因模型:OR=1.47,95%CI:1.25~1.74,P<0.01;显性遗传模型:OR=1.37,95%CI:1.14~1.65,P<0.01)。敏感性分析显示结果稳定,倒漏斗图及Begg检验提示存在发表偏倚可能性小。结论 MMP-9基因C-1562T多态性与中国人缺血性脑卒中相关,可能是缺血性脑卒中发病的危险因素。
Objective To evaluate the relationship between the C-1562T polymorphism of matrix metalloproteinase-9 (MMP-9) gene and ischemic stroke in Chinese population. Methods A case-control study published before November 2015 on the polymorphism of MMP-9 gene C-1562T in Chinese ischemic stroke patients was performed by Meta-analysis. Results A total of 8 case-control studies were included. Meta-analysis showed that the C-1562T polymorphism of MMP-9 gene was associated with the incidence of ischemic stroke in Chinese population (odds ratio 1.47, 95% CI 1.25-1.74, P <0.01; dominant genetic model: OR = 1.37, 95% CI: 1.14-1.65, P <0.01). Sensitivity analysis showed that the results were stable, inverted funnel chart and Begg test suggest the possibility of publication bias is small. Conclusion The C-1562T polymorphism of MMP-9 gene is associated with ischemic stroke in Chinese population and may be a risk factor for ischemic stroke.