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目的：探讨阻塞性睡眠呼吸暂停综合征（ＯＳＡＳ）患者夜间低氧血症与室性心律失常的相互关系。方法：选择拟诊ＯＳＡＳ患者６０例和正常对照组２０名进行多导睡眠图检查。结果：①ＯＳＡＳ组中，睡眠呼吸暂停低通气指数（ＡＨＩ）、动脉血氧饱和度（ＳａＯ２）降低大于０．０４的总次数、ＳａＯ２低于０．９０的时间及其降低幅度均明显高于正常对照组（均Ｐ＜０.００１）；睡眠中ＳａＯ２最低值、平均值均低于对照组（均Ｐ＜０．００１）；在轻、中、重度组间两两比较，上述指标也有显著性意义（均Ｐ＜０．００１）；②轻、中、重度ＯＳＡＳ患者室性期前收缩（ＰＶＣ）的发生率分别为５０％、６５％、８５％；与正常对照组（２５％）相比，轻度组无显著性意义（Ｐ＞０．０５），而中、重度组的ＰＶＣ发生率则显著增高（Ｐ＜０．０５，Ｐ＜０.０１）；在轻、中、重度组间两两比较，ＰＶＣ发生的总次数和每小时的发生次数也有显著性意义（均Ｐ＜０．０１）；无论轻、中、重度ＯＳＡＳ患者的非快速眼动睡眠（ＮＲＥＭ）期ＰＶＣ的发生次数都显著高于快速眼动睡眠（ＲＥＭ）期（均Ｐ＜０．００１）。结论：ＯＳＡＳ病情越严重，睡眠时ＳａＯ２降低的程度越显著，低氧血症也越明显。ＰＶＣ的发生与睡眠时相?
Objective: To investigate the relationship between nocturnal hypoxemia and ventricular arrhythmia in patients with obstructive sleep apnea syndrome (OSAS). Methods: Sixty OSAS patients and 20 normal controls were selected for polysomnography. Results: ①In the OSAS group, the total number of sleep apnea-hypopnea index (AHI) and arterial oxygen saturation (SaO2) decreased by more than 0.04, and the time of SaO2 less than 0.90 and its decrease were significantly higher than those of normal (All P <0.001). The lowest and average values of SaO2 in sleep were lower than those in control group (all P <0.001). The above indexes were also significantly different between the mild, moderate and severe groups (P <0.001). The incidence of premature ventricular contractions (PVC) in mild, moderate and severe OSAS patients was 50%, 65% and 85% respectively. Compared with the normal control group (25%) (P> 0.05), while the incidence of PVC in moderate and severe group was significantly higher (P <0.05, P <0.01); in mild, moderate and severe groups In any pairwise comparison, the total number of occurrences of PVC and the number of occurrences per hour were also significant (all P <0.01); no matter in mild, moderate or severe OSAS patients REM sleep occurrence number (of NREM) of PVC is significantly higher than that of rapid eye movement (REM) sleep stage (all P <0.001). Conclusion: The more severe the OSAS, the more significant the decrease of SaO2 during sleep and the more obvious the hypoxemia. PVC occurrence and sleep phase?