论文部分内容阅读
目的 在改良法自体血血栓栓塞性脑卒中大鼠模型上使用尿激酶静脉溶栓 ,试图建立理想化的溶栓治疗脑卒中研究的模型体系。方法 治疗组于大脑中动脉闭塞后 0 .5h尿激酶进行静脉溶栓。 5h和2 4h后进行神经功能缺损评分 ,用TTC染色法测定梗死灶体积 ,并观察梗死后 6h的脑组织病理变化。结果 此模型可产生范围较恒定的梗死灶 ,治疗组梗死灶体积明显小于对照组 (P <0 .0 1)。但两组 5h和 2 4h神经功能缺损评分无显著性差异。结论 这种模型超早期使用尿激酶静脉溶栓疗效好 ,由于可能存在缺血性神经元顿抑 ,尽管溶栓组脑梗死体积减小 ,但早期神经功能恢复不明显。
Objective To establish a model system of ideal thrombolytic therapy for stroke by using intravenous thrombolysis of urokinase in a modified autologous thromboembolic stroke rat model. Methods The treatment group received 0.5 urokinase for intravenous thrombolysis after occlusion of the middle cerebral artery. Neurological deficit scores were measured at 5h and 24h, infarct volume was measured by TTC staining, and histopathological changes at 6h after infarction were observed. Results The model produced a relatively constant range of infarct size. The volume of infarction in the treatment group was significantly smaller than that in the control group (P <0.01). However, there was no significant difference between the two groups in 5h and 24h neurological deficit scores. Conclusion This model of ultra-early use of intravenous thrombolytic effect of urokinase, due to possible ischemic neuronal stunned, despite thrombolytic group decreased cerebral infarction volume, but early neurological recovery was not obvious.