感染是免疫受损宿主最主要的合并症和致死原因,其中以机会性感染(OI)问题最为突出,其引起的临床表现常不典型,给诊断带来了很大的困难,因此如何防治这类病人的OI 问题已成为重要课题之一。原发性免疫缺陷病(PID)是该研究领域中独特的自然生物模型,通过机会性病原体(OA)在 PID宿主中引起组织病变自然经过的观察,有助 Infection is the most common cause of comorbidities and deaths in immunocompromised hosts. Of these, the most prominent are the opportunistic infections (OI), which are often not typical of clinical manifestations, posing great difficulties in diagnosis, so how to prevent this The OI problem of patients has become one of the important topics. The primary immunodeficiency disease (PID) is a unique natural biological model in this field of study. The observation that natural opportunistic pathogens (OA) cause natural histological changes in PID hosts contributes