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目的探讨焦炉工外接触等级与尿中1-羟基芘物质的量浓度的关系,同时研究血清肿瘤坏死因子-α(TNF-α)水平能否作为焦炉工多环芳烃(PAH)的接触评价指标以及TNF-α与1-羟基芘物质的量浓度的关系。方法以某焦化厂86名生产工人和35名对照者为研究对象,采集血清和班后尿,并收集个人信息,检测血清中TNF-α水平,用高效液相色谱法测定尿中1-羟基芘。结果焦炉工尿1-羟基芘物质的量浓度(4.78±2.09)μmol/molCr显著高于对照组[(2.12±1.81)μmol/molCr,P<0.001],并呈炉顶>炉侧>炉底>对照组的趋势。与外接触呈显著相关性(r=0.727,P<0.001);在同样外接触条件下,吸烟量显著影响尿中1-羟基芘的水平(P<0.05);焦炉工血清中TNF-α水平(30.1±2.0)μg/L明显高于对照人群[(17.7±1.8)μg/L,P<0.001];焦炉工尿1-羟基芘水平与血清中TNF-α呈弱相关(r=0.316,P<0.001)。结论焦炉工尿中1-羟基芘水平与外接触等级存在良好的剂量-效应关系,可反映PAH接触个体的内剂量水平;焦炉工人血清TNF-α有可能作为PAH接触评价的参数。
OBJECTIVE To investigate the relationship between the level of exposure to coke oven and the concentration of 1-hydroxypyrene in urine and to investigate whether serum TNF-α level can be used as PAH in coke oven workers Evaluation index and the relationship between the concentration of TNF-α and 1-hydroxypyrene. Methods A total of 86 workers and 35 control workers in a coking plant were selected as research objects. Serum and urine were collected after class and personal information was collected. The level of serum TNF-α was measured. The contents of urinary 1-hydroxy Pyrene. Results The concentration of urinary 1-hydroxypyrene (4.78 ± 2.09 μmol / molCr) in coke oven workers was significantly higher than that in the control group [(2.12 ± 1.81) μmol / molCr, P <0.001] Bottom> control group trend. (R = 0.727, P <0.001). Under the same external exposure, the level of 1-hydroxypyrene in urine was significantly affected (P <0.05). The level of TNF-α (30.1 ± 2.0) μg / L was significantly higher than that of the control group [(17.7 ± 1.8) μg / L, P <0.001]. The level of 1-hydroxypyrene in coke oven workers was weakly correlated with the level of TNF- 0.316, P <0.001). Conclusion There is a good dose-effect relationship between the level of 1-hydroxypyrene and the level of external exposure in coke oven workers, which can reflect the internal dose level of PAH exposure individuals. Coke oven workers' serum TNF-α may be used as a parameter to evaluate PAH exposure.