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目的:探讨早期肠外营养(EPN)对极低出生体重儿(VLBW)体重增长的影响和不良反应发生情况。方法:将体重<1 500 g的极低体重儿随机分为治疗组(40例)和对照组(38例)。治疗组病儿出生后24 h即应用含脂肪乳的PN,并辅以少量的胃肠道喂养和非营养性吸吮。对照组应用不含脂肪乳的PN,其他同治疗组。10 d后,检测体重变化、相关生化指标和并发症情况。结果:治疗组病儿每天体重增长幅度明显高于对照组,未增加病儿患氮质血症、高胆红素和胆汁淤积等的危险性。两组病儿并发症的发生率无显著性差异(P>0.05)。结论:应用脂肪乳剂EPN,能缩短病儿平均住院时间,促进体重增长。
Objective: To investigate the effect of early parenteral nutrition (EPN) on the weight gain and the incidence of adverse reactions in very low birth weight infants (VLBW). Methods: Very low birth weight children weighing <1500 g were randomly divided into treatment group (40 cases) and control group (38 cases). Treatment group, 24 hours after birth, the application of fat-containing PN, supplemented by a small amount of gastrointestinal and non-nutritional sucking. Control group without fat emulsion PN, other with the treatment group. After 10 days, the changes of body weight, related biochemical indexes and complications were detected. Results: The daily weight gain of sick children in the treatment group was significantly higher than that of the control group, and did not increase the risk of azotemia, hyperbilirubin and cholestasis in the sick children. There was no significant difference in the incidence of complications between the two groups (P> 0.05). Conclusion: The application of fat emulsion EPN can shorten the average length of hospital stay and promote weight gain.