人们认识到病毒可以作为选择性肿瘤杀伤制剂已有很长的历史 ,但是进一步用基因工程技术,改造基因结构使病毒具有肿瘤特异性则是近些年来才开始的研究,并且已经取得初步成功。本文对病毒在肿瘤细胞内特异性增殖的途径 ,以及增殖性病毒研究的热点及问题进行了讨论 It has been recognized that viruses can be used as selective tumor killing agents for a long time, but further genetic engineering techniques to modify the genetic structure to make the virus tumor-specific have only begun in recent years, and initial success has been achieved. This article discusses the specific proliferation of viruses in tumor cells and the research hotspots and problems of proliferative viruses.